Celebrex Heart Attacks

Vioxx / Celebrex

Do I have a Celebrex renal failure case?
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What is Celebrex?

Learn about these NSAIDs, the recall, & the risks.


What is the problem?

...studies associate Vioxx with heart problems, kidney damage, aseptic menin...


Who is responsible for Celebrex renal failure?

Safety Risks to patients due to lack of warnings.


What is being done about Celebrex renal failure?

Class action lawsuit filed against the maker of Vioxx.


What can you do if you suffer from Celebrex renal failure?

You may be entitled to compensation for damages


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What is Kidney Failure?

  What is the Celebrex Renal Failure relationship?
  Is the benefit of Celebrex worth the risk of Celebrex renal failure?
  What problems, other than renal failure, does Celebrex cause?
  Is the cost of Celebrex worth the risk of Celebrex renal failure?
  More information about Celebrex renal failure
  References related to Celebrex renal failure

Vioxx and Kidney Failure

Vioxx and Celebrex, two popular prescription medications used to treat chronic pain associated with arthritis and other conditions, have been linked to renal failure. These two drugs belong to a new class of pain medications known as COX-2 inhibitors. Drug Safety, a medical journal that reports on the safety of prescription medications, published a study in 2002 warning that "Physicians should be aware that serious or life-threatening renal failure has been reported in patients with normal or impaired renal function after short-term therapy with celecoxib and rofecoxib." In addition to the published reports, Merck, the manufacturer of Vioxx, has received reports of several cases of possible kidney failure associated with their drug. Pharmacia, the manufacturer of Celebrex, has received similar reports regarding renal failure and the lack of safety of their medication.

What is Celebrex renal failure?

Renal failure is a serious condition. Damaged kidneys are unable to excrete sufficient amounts of waste and other toxic substances from the body. According to the Merck Manual of Diagnosis and Therapy, the textbook of medicine most widely used by health care professionals in the U.S. and worldwide, this build up of toxins may cause the patient to feel weary, tire easily, and become less mentally alert. Increased levels of toxins may lead to muscle twitches, muscle weakness, and cramps. Convulsions (seizures) may result if high blood pressure or abnormalities in the blood chemistry cause the brain to malfunction. The digestive tract is also affected, causing a loss of appetite, nausea, vomiting, and inflammation of the lining of the mouth (stomatitis). In its advanced stages, kidney failure often results in intestinal ulcers and bleeding.

What is the relation between Celebrex and renal failure?

Both Vioxx and Celebrex have been associated with kidney failure and other complications. Research published in the International Urology and Nephrology journal reports acute renal failure due to treatment with COX-2 inhibitors. Doctors involved in the research warn that caution about kidney failure should be used when treating patients with Vioxx or Celebrex. Other research warned that Vioxx and Celebrex carried the same risk of kidney damage as other medications used to treat pain. The researchers found that Vioxx and Celebrex "did not differ from a nonselective nonsteroidal anti-inflammatory drug (naproxen), in influencing renal function as measured by urinary sodium excretion, systolic and diastolic blood pressure, creatinine clearance, or weight change."

Is the benefit of Celebrex worth the risk of renal failure?

Developed and approved to treat the pain of arthritis, Vioxx and Celebrex have been used to treat everything from back ache to menstrual cramps. Representatives from Merck and Pharmacia began an aggressive marketing campaign, directed towards doctors who could prescribe the drug, in some cases telling doctors they could prescribe the medication for purposes other than those approved by the FDA. The companies also conducted heavy direct-to-consumer advertising campaigns, telling consumers to ask their doctor about Vioxx, or to ask if Celebrex was right for them.

Vioxx and Celebrex belong to a class of drugs designed to replace nonsteroidal anti-inflammatory drugs (NSAIDs) like naproxen and ibuprofen. Merck and Pharmacia advertised their respective drugs as safer, claiming there was a lower chance of ulcers and other complications associated with NSAIDs. But some doctors and consumer advocacy groups have charged that the medications are little more than super-expensive versions of aspirin. The British Medical Journal (BMJ) has asserted that the makers of Celebrex were "over-optimistic" about their research data. A report issued by the FDA said that research on the new pain medications "did not show a safety advantage in upper gastrointestinal events for Celebrex compared to either ibuprofen or diclofenac." Pharmacia argued that the study was not a fair representation of their product.

What problems, other than renal failure, does Celebrex cause?

Unfortunately, problems began to appear among patients who had received prescriptions for the new medications shortly after the drugs went to market. In addition to kidney problems, Vioxx and Celebrex have been associated with heart problems, aseptic meningitis and slow healing of bone fractures.

Is the cost of Celebrex worth the risk of renal failure?

Some doctors believe that the medications are no more effective than older, less expensive drugs. One big difference is in the price: Patients pay as much as $134.99 for 30 50-mg Vioxx capsules, and $96.99 for 30 200-mg Celebrex pills. This compares to $16.69 for 30 500-mg pills of generic naproxen. An over-the-counter bottle of 24 tablets of 200-mg ibuprofen (Advil) cost $3.99.


References related to Celebrex renal failure

Ahmad SR, et al (2002) "Renal failure associated with the use of celecoxib and rofecoxib." Drug Safety; 25(7):537-44

Papaioannides D., et al (2001). "Acute renal dysfunction associated with selective COX-2 inhibitor therapy." International urology and nephrology, 33(4):609-11.

Schwartz, JI., et al (2002) "Comparison of rofecoxib, celecoxib, and naproxen on renal function in elderly subjects receiving a normal-salt diet." Clinical pharmacology and therapeutics, 72(1):50-61

More information about Celebrex renal failure:

“A woman who developed kidney failure after taking the popular arthritis drug Vioxx has raised more questions about the safety of this and similar drugs… ”


“Vioxx and Celebrex are supposed to relieve pain, but their makers are feeling plenty of pain. In recent months the top-selling arthritis drugs -- known as COX-2 inhibitors because they block the COX-2 enzyme, which causes inflammation and thus pain -- have been associated with Celebrex renal failure, heart problems, kidney damage…”


“…The medical journal the Lancet published a study associating Vioxx with kidney failure, and other studies have associated both Vioxx and Celebrex with heart problems, kidney damage, aseptic meningitis, and slow healing of bone fractures….”


“Toxic Alert – Many common drugs can damage kidney and liver. Although often assumed to be safe, prescription and over-the-counter medications can cause serious adverse reactions, especially in certain high-risk populations. Acetaminophen (Tylenol) and ibuprofen (Advil), just two categories of drugs that can cause adverse reactions, are ingredients in more than 200 OTC and prescription drug preparations…”



Do I have a Celebrex renal failure case?


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