According to Wyeth, PREMPRO is now being offered in a new formulation that is promoted to provids women with relief from menopausal symptoms while using lower doses of hormones than other PREMPRO drugs, such as 0.625 mg/2.5 mg. Wyeth stated that they introduced PREMPRO 0.3 mg/1.5 mg as the lowest combination of conjugated estrogens (CE) and medroxyprogesterone acetate (MPA) available today.
On their web site, you will find information about menopausal health, menopausal symptoms, vaginal health, and low dose hormone therapy.
Wyeth, the main defendant in these Prempro cases, offers estrogen and progestin in a single pill (PREMPRO), an estrogen-only pill (PREMARIN), and a vaginal cream (PREMARIN® [conjugated estrogens] Vaginal Cream).
On its website, Wyeth lists the following warnings that Woman need to know about PREMPRO, PREMARIN, PREMARIN.
- "Estrogens increase the chances of getting cancer of the uterus. A woman should report any unusual vaginal bleeding right away while taking these products. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Her health care provider should check any unusual vaginal bleeding to find out the cause. Do not use estrogens with or without progestins to prevent heart disease, heart attacks, or strokes. Using estrogens with or without progestins may increase a woman's chances of getting heart attacks, strokes, breast cancer, and blood clots. A woman and her health care provider should talk regularly about whether she still needs treatment with estrogens. PREMARIN® (conjugated estrogens tablets, USP) is used after menopause to reduce moderate to severe hot flashes and to treat moderate to severe dryness, itching, and burning in or around the vagina; and to help reduce a woman's chances of getting osteoporosis (thin, weak bones).
- "PREMPRO (conjugated estrogens/medroxyprogesterone acetate tablets) is used after menopause in women with a uterus to reduce moderate to severe hot flashes; to treat moderate to severe dryness, itching, and burning in or around the vagina; and to help reduce a woman's chances of getting osteoporosis (thin, weak bones).
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"PREMARIN® (conjugated estrogens) Vaginal Cream is indicated in the treatment of atrophic vaginitis and kraurosis vulvae.
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"PREMARIN, PREMPRO, and PREMARIN Vaginal Cream should be used for the shortest duration consistent with a woman's treatment goals and risks. If a woman does not have symptoms, non-estrogen treatments should be carefully considered before taking PREMARIN and PREMPRO solely for the prevention of postmenopausal osteoporosis. If a woman is using PREMARIN or PREMPRO only to treat the symptoms of vaginal dryness, topical therapies should be considered first.
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"In a clinical trial, the most commonly reported ( >5%) side effects of PREMARIN were vaginitis due to yeast or other causes, vaginal bleeding, painful menstruation, and leg cramps.
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"In a clinical trial, the most commonly reported ( >5%) side effects of PREMPRO 0.45 mg/1.5 mg and PREMPRO 0.625 mg/2.5 mg were breast pain/enlargement, vaginitis due to yeast or other causes, leg cramps, vaginal spotting/bleeding, and painful menstruation. In a clinical trial, there was no difference in the commonly reported ( >5%) side effects for women taking PREMPRO 0.3 mg/1.5 mg compared to those taking placebo.
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"The most commonly reported side effects of PREMARIN Vaginal Cream are vaginitis, pain, breast pain, and pruritus (itching).
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"PREMARIN, PREMPRO, and PREMARIN Vaginal Cream should not be used if a woman has unusual vaginal bleeding, has or had cancer of the breast or uterus, had a stroke or heart attack in the past year, has or had blood clots, has liver problems, is allergic to any of the ingredients in PREMARIN, PREMPRO, or PREMARIN Vaginal Cream, or thinks she may be pregnant."
We are no longer accepting inquiries for Hormone Replacement Therapy cases.
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