Are Premarin and Prempro safer in lower doses?
April 1, 2004 09:28

The dose of Prempro used in the WHI study was 0.625 mg, which is the same as 0.625 mg Premarin (conjugated estrogens) plus 2.5 mg medroxyprogesterone acetate (progestin). It is not known whether Premarin and Prempro are safer in lower doses. Generally, medicines should be used at the lowest effective dose. The FDA cannot make further recommendations until studies are performed using lower doses.