FenPhen Settlement Information - The PPH side-effects of FenPhen increasingly became the focus of media and a source of worry in the medical community. July 8, 1997 CNN reported about FenPhen in an article to be published August 27, 1997 in the New England Journal of Medicine revealing 24 Midwestern women had developed heart-valve disease as a result of FenPhen diet pills.

For FenPhen users, this is significant, because pre-publication release about a medical article is unusual, reserved for only most serious public health matters, and highlights the urgency of the problem. Prior to this, FenPhen's most serious known side-effect was primary pulmonary hypertension (PPH), a serious and potentially-fatal disorder where arteries supplying the heart are constricted, producing abnormally high blood pressure, shortness of breath and fatigue.

FenPhen research revealed that those using these drugs for more than three months increase risk of PPH from 1 or 2 in 1 million patients to 18 in l million. Other studies suggest 43 in 1 million. According to the article, Fen in FenPhen alters serotonin metabolism in the brain while the phen part of FenPhen interferes with the pulmonary clearance of serotonin in the blood stream, which may explain its association with FenPhen PPH. Significantly, the article, states the association of valvular problems with FenPhen is not likely due to chance and that candidates for the FenPhen drug therapy should be informed about this serious potential adverse side effects.

As a result of adverse effects, the FDA sent a letter on July 8, 1997 to doctors prescribing the drug asking them to immediately find out if their patients experienced symptomatology suggestive of a heart valve problem. When untreated, valve problems can lead to congestive heart failure. Valve damage causes blood to leak back into the heart, making the heart work harder.

See: FDA resources on dangerours drugs

Likewise, the French Government restricted the use of Redux to the morbidly obese after it was discovered there were an estimated 20 deaths a year associated with Redux. The state of Tennessee has altogether banned the sale of FenPhen.

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