A dream takes flight
January 3, 2005 09:53

KRISTA Bell has always wanted to be a professional cheerleader when she grows up.

First in Pop Warner groups and later in a national competitive squad, the 16-year-old with pixie-like beauty and a bright smile has been shouting and jumping and back-handspringing for most of her life.

Doctors at Children's Hospital of Philadelphia did a biopsy and learned that Bell had Ewing's Sarcoma, a cancer that affects the bones and soft tissue.

Barry Sugarman, B.S.ENGR., All Rights Reserved. Phone 310-355-6046, FAX 310-454-9592

1) It is very important to have an MRI of the area,...
2) The confirmation of the diagnosis of Ewing's Sarcoma may only be made after a biopsy has been taken ... See here: http://www.findcancerexperts.com Phone: 301-770-6008, Fax: 301-231-4987
3) It is absolutely essential that the recognized chemotherapy, surgery, and radiation protocol for Ewing's Sarcoma be started immediately, ... Richard Womer, M.D., Children's Hospital of Philadelphia, Division of Oncology, 324 South 34th St., Philadelphia PA 19104, Phone: 215-590-2229 Fax: 215-590-4183, Email: rwomer@mail.med.upenn.edu .
4) There is at least one study that says that treatment results are better for sarcomas at a recognized sarcoma treatment facility... http://www.stjude.org Phone: 901-495-3300.
5) With regard to orthopedics, you definitely need to consult with an orthopedic oncologist.... The web site is: http://msts.org , Phone: 615-343-4400, Fax: 615-343-1028.
6) Usually, the 12 week point in therapy calls for consideration of additional radiation, and/or other non-surgical techniques and/or surgery as an additional therapy. ... See the orthopedic section of our front page at: http://www.cureourchildren.org
7) If the initial diagnosis includes metastatic disease, that is tumors in multiple locations, consider having stem cells drawn immediately to leave open the option of high-dose chemotherapy with autologous (your own) stem cell transplant at the conclusion of the entire chemotherapy protocol. ... the protocol chairman is Alan W. Craft, M.D., Phone: 011-44-191-202-3010, Fax: 011-44-191-202-3022 (United Kingdom), Email: AW.Craft@newcastle.ac.uk .
8) It is important to contact your child's school in writing to request an Individualized Education Plan (IEP) so that the child receives educational services during treatment. ...
9) Ewing's Sarcoma is a very, very aggressive disease. At every point where you have a choice, it is wise to weight heavily on the more aggressive treatment option. Please call me at your earliest convenience to discuss.

A former cancer patient who doctors were convinced had become infertile has given birth to a baby boy in Edinburgh.

... She developed the malignant bone cancer Ewing's sarcoma more than six years ago. After undergoing successful treatment she did not have regular periods and required hormone replacement therapy to prevent symptoms of the menopause. ...

(BBC)

MIAMI (Billboard) - Salsa singer Tito Nieves has embarked on a campaign to lose. Nieves -- whose most recent single, "Fabricando Fantasias," hit No. 1 on the Billboard Tropical Airplay chart last year -- has announced that he plans to lose a whopping 100 pounds. He currently weighs in at 240 pounds. So committed is he to the endeavor that he announced it on Univision's popular TV show "Don Francisco." Additionally, Nieves is scheduled to have regular on-camera weigh-ins. When he is done with the program, he says, he will write a book about his experience. All proceeds from the book's sales will go to the Ommy Nieves Foundation at New York's Memorial Sloan Kettering Cancer Center. The foundation was created in memory of Nieves' eldest son, Ommy, who died last year of Ewing's sarcoma at the age of 24. Donations to the foundation can be made through http://www.titonieves.com.

About a month ago, Justine Ula got a chance to make a wish. She wanted to go shopping.

The trip is a gift from Make-A-Wish of Northeast Ohio. Justine, 14, is undergoing treatment for Ewing's sarcoma, a type of bone cancer that tends to strike people between the ages of 10 and 20. She was diagnosed in May and has since been through chemotherapy, surgery, radiation treatment and now, a second round of chemotherapy.

http://www.vindy.com/premium/local/282331467880627.php

One week, 9-year-old Daniel Lee was making touchdowns for his football team and the next he was at University of California, Davis Medical Center getting a biopsy for a softball-size mass in his pelvic area.

The diagnosis was Ewing's Sarcoma, a fast-growing cancer that is usually found in children and young adults. Ewing's can occur in any bone in the body; the most common sites are the pelvis, thigh, lower leg, upper arm, and rib.

http://www.lassennews.com/News_Story.edi?sid=2441&mode=thread&order=0

Ewing sarcoma/primitive neuroectodermal tumor is classically a tumor of the soft tissue or bone in children and young adults, but several cases have been described in patients of all ages. Within the last decade, the clinicopathologic spectrum of Ewing sarcoma/ primitive neuroectodermal tumor has been markedly expanded by recognition that the tumor may also have a visceral origin. We describe a case of primitive neuroectodermal tumor arising in the stomach of a 66-year-old woman. The neoplasm was excised using a radical surgical procedure. Microscopically, the tumor was made up of solid nests and sheets of round cells. Immunohistochemically, the tumor cells showed immunoreactivity for CD99, S100, neuron-specific enolase, and vimentin. A multiplex real-time polymerase chain reaction assay detected an EWS-ERG fusion. To our knowledge, this is the first description of a primitive neuroectodermal tumor arising in the stomach. (Arch Pathol Lab Med. 2005;129:107-110)

Tumors of the Ewing sarcoma/primitive neuroectodermal tumor (ES/ PNET) family are round cell sarcomas occurring mainly in young patients, the majority of whom are younger than 30 years, with a peak incidence during the second decade of life. There tends to be a broader age range for PNET, with a significant number of patients older than 40 years.1-4 These tumors show a predilection for deep soft tissues and have been described infrequently in visceral sites.1-11 We report a case of PNET occurring in the stomach of a 66- year-old woman; the diagnosis was confirmed by molecular techniques.

COMMENT
Ewing sarcoma and PNET are now generally considered a single entity, the ES/PNET family of tumors.1,2,5 Virtually all ES/PNETs appear to express a chromosomal translocation resulting in fusion of the EWS gene at 22q12 with a member of the ETS-related oncogenes, that is, FL/2 (Ilq24), EKG (21q22), ETVl (7p22), EMF (17ql2), and FEV (2q33)."14 The term primitive neuroectodermal tumor has been used for tumors that demonstrate neuroectodermal features assessed by 1 or more of the following modalities: light microscopy, immunohistochemistry, and electron microscopy.3

The most important differential diagnosis in this case (adult older than 40 years) was considered to be carcinoma (undifferentiated carcinoma or poorly differentiated neuroendocrine carcinoma). The other main differential diagnoses were considered to be lymphoma, melanoma, synovial sarcoma, rhabdomyosarcoma, and small round cell desmoplastic tumor. This differential diagnosis is further complicated by the rare or exceptional occurrence of most of these entities in the stomach. References
1. Weiss SW, Goldblum JR. Primitive neuroectodermal tumors and related lesions. In: Weiss SW, Goldblum JR, eds. Enziger and Weiss's Soft Tissue Tumors. 4th ed. St Louis, Mo: Mosby lnc; 2001:1289- 1308.
2. Dehner LP. Primitive neuroectodermal tumor and Ewing's sarcoma. Am J Surg Pathol. 1993;17:1-13.
3. Ushigome S, Machinami R, Sorensen PH. Ewing sarcoma/primitive neuroectodermal tumour (PNET). In: Fletcher CDM, Unni KK, Mertens F, eds. Ethology and Genetics of Tumours of Soft Tissue and Bone. Lyon, France: IARC Press; 2002: 297-300. World Health Organization Classification of Tumours; vol 5.
4. Hashimoto H, Tsuneyoshi M, Daimaru Y, et al. Extraskeletal Ewing's sarcoma: a dinicopathologic and electron microscopic analysis of 8 cases. Acta Pathol ]pn. 1985;35:1087-1098.
5. O'Sullivan MJ, Perlman E), Furman J, Humphrey PA, Dehner LP, Pfeifer JD. Visceral primitive neuroectodermal tumors: a dinicopathologic and molecular study. Hum Pathol. 2001 ;32:1109-111 5.
6. Kawauchi S, Fukuda T, Miyamoto S, et al. Peripheral primitive neuroectodermal tumor of the ovary confirmed by CD99 immunostaining, karyotypic analysis, and RT-PCR for EWS/FLI-1 chimeric mRNA. Am J Surg Pathol. 1998;22: 1417-1422.
7. Maesawa C, lijima S, Sato N, et al. Esophageal extraskeletal Ewing's sarcoma. Hum Pathol. 2002;33:130-132.
8. Colecchia M, Dagrada G, Poliani PL, Messina A, Pilotti S. Primary primitive peripheral neuroectodermal tumor of the prostate: immunophenotypic and molecular study of a case. Arch Pathol Lab Med. 2003;! 27:190-193.
9. Movahedi-Lankarani S, Hruban RH, Westra WH, Klimstra DS. Primitive neuroectodermal tumors of the pancreas: a report of seven cases of a rare neoplasm. Am J Surg Pathol. 2002;26:1040-1047.
10. Jimenez RE, Folpe AL, Lapham RL, et al. Primary Ewing's sarcoma/primitive neuroectodermal tumor of the kidney: a clinicopathologic and immunohistochemkal analysis of 11 cases. Am J Surg Pathol. 2002:26:320-327.
11. Kushner BH, Hajdu Sl, Culati SC, Erlandson RA, Exelby PR, lieberman PH. Extracranial primitive neuroectodermal tumors: the Memorial Sloan-Kettering Cancer Center experience. Oncer. 1991:67:1825-1829.
12. Peter M, Gilbert E, Delattre O. A multiplex real-time PCR assay for the detection of gene fusions observed in solid tumors. Lab Invest. 2001 ;81:905-912. 13. Delattre O, Zucman ), Plougastel B, et al. Gne fusion with ETS DNAbinding domain caused by chromosome translocation in human tumors. Nature. 1992:359:162-165.
14. Delattre O, Zucman J, Melot T, et al. The Ewing family of tumors: a subgroup of small-round-cell tumors defined by specific chimeric transcripts. N Engl J Meet. 1994:331:294-299.
15. Coindre JM. lmmunohistochemistry in the diagnosis of soft tissue tumours. Histopathology. 2003:43:1-
16. Raoulin Soulard, MD; Valre Claude, MD; Philippe Camparo, MD; Jean- Philippe Dufau, MD; Patrick Saint-Blancard, MD; Philippe Gros, MD

http://newsnet.byu.edu/story.cfm/54151
Fourteen-year-old Parker Jensen led the Pledge of Allegiance on the floor of the House of Representatives Thursday morning as a chemotherapy-free, cancer-free teenager. Jensen and his parents were invited to Salt Lake City to participate in the day?s ceremony as quasi-celebrities. The Jensens became the subject of national media attention when 12-year-old Parker was diagnosed with Ewing's sarcoma, a rare form of cancer in April 2003. But the media flare-up came when his parents refused to start him on chemotherapy and were accused of kidnapping him to avoid treatment. Charges were dropped in October 2003 and now, the Jensens say they are getting on with their lives.

http://brownbears.collegesports.com/sports/m-footbl/spec-rel/012905aab.html
Providence, RI - Lawrence Rubida will be remembered for the way he lived. For how he attacked the final battle for his life to overcome Ewing's Sarcoma cancer with the same zest and zeal that he played football for Brown. The Brown community is deeply saddened by the death of Brown football tri-captain Lawrence Rubida, Class of 2005, after a 9-month battle with Ewing's Sarcoma, a rare form of childhood bone cancer. Rubida passed away at 2:30 a.m. Saturday morning (1-29-05) at the Halquist Memorial Hospice near his home in Arlington, Virginia. Rubida's mom and dad, his sister, his girlfriend, Kim Highlund, Bears' coach Phil Estes and assistant coach Frank Sheehan were present at his death. Rubida's indomitable spirit in battling cancer energized the Brown community, his Ivy League brethren, and cancer survivors throughout the country in a fundraising effort to help defray Rubida's medical costs and to increase awareness for Ewing's Sarcoma. ...

Brown football tri-captain Lawrence Rubida, lost his battle with Ewing's Sarcoma, a rare form of a childhood bone cancer, on Saturday morning. The senior was 23 years old. Rubida was diagnosed with the disease after doctors found a tumor on his hip in the spring of 2004.