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CELEBREX : Celebrex News Log Home : 2004-12-19 : Article
Pfizer Inc. said it found an increased risk of heart attacks and strokes for patients taking high dosages of its top-selling arthritis painkiller Celebrex, the same problem that led to the withdrawal of its one-time competitor Vioxx.
In the 2,000 patient study, 15 individuals taking 400 mgs, 20 patients taking 800 mgs and 6 patients on placebo suffered either a cardiac-related death, heart attack or stroke.
"The challenge for Pfizer now is to show why this drug should be chosen," said FitzGerald, a cardiologist at the University of Pennsylvania.
"You can't say as a result of this study that doses under 400 milligrams are absolutely safe," said Dr. Eric Matteson, a professor of medicine in the division of rheumatology at the Mayo Clinic in Rochester, Minn.
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