- Blood Group Antibodies
- Hepatitis B Surface Antigen
- Antibody to Hepatitis B Core
- Antibody to Hepatitis C virus
- Alanine Aminotransferase (ALT)
- Antibody to HTLV- 1 and 2
- Antibody to HIV 1 and 2
- Syphilis
- History of any condition that can affect the quality and long-term performance of the bone tissue1
- Bone cancer
- Old, brittle bones
- Tissues with culture results yielding bacterial contamination like Clostridium and Streptococcus pyogene should be discarded.
- Exclude bone collection from donors where autopsy reveals occult disease.
Tests that are not routinely done but should be:
- Cytomegalovirus
- Epstein-Barr virus
- West Nile Virus
- Chagas disease
- Toxoplasmosis
- Malaria
Donors should be additionally screened for:
- Sepsis
- Vaccinia (smallpox vaccination)
- Severe Acute Respiratory Syndrome (SARS)
- Creutzfeldt-Jakob Disease (CJD) and variant Creutzfeldt-Jakob Disease (vCJD)
What are the risk? (Incubation periods for disease:
- Hepatitis B: 45 to 160 days, average 120 days1
- Hepatitis C: 14 to 180 days, average 45 days1
- HTLV: incubation period of 10-40 years 2
- HIV: 2 weeks to 3 months, but could be up to 6 months1
- Syphilis: 10 to 90 days1
- Cytomegalovirus:1 to 4 months after transplant1
- Epstein-Barr virus: 4 to 6 weeks2
- West Nile Virus: 2 to 15 days3
- Chagas disease: asymptomatic, 20 to 40 days4
- Toxoplasmosis: 5 to 23 days5
- Malaria: 7 to 306 days
What can happen?
An Allograft bone was from the hospital bone bank in 1984 and a
Recipient diagnosed with Pneumocystis (PCP) AIDS in 1988 and a Donor diagnosed with AIDS in 1986
