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Hyperosmolar Coma Zyprexa
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Zyprexa & Diabetes
Do you have a Zyprexa diabetes case?
If you are currently taking Zyprexa® and have concerns about its safety, you should consult with your doctor regarding your treatment options. Under no circumstances should you discontinue taking any medication, including Zyprexa®, without first consulting with your doctor.
Synonyms and related keywords: hyperosmolar nonketotic state, HNS, hyperosmolar hyperglycemic syndrome, diabetic hyperosmolar state, hyperglycemic hyperosmolar nonketotic syndrome, hyperosmolar hyperglycemic nonketotic coma, nonketotic hypertonicity
Hyperglycemia and the rise in concentration of plasma proteins that follow intravascular water loss cause a hyperosmolar state. Hyperosmolarity of the plasma triggers antidiuretic hormone release, which ameliorates renal water loss. Hyperosmolarity also stimulates thirst, a defense mechanism that is impaired in people dependent on others for care.
Don't delay in
learning more
about the settlement of many Zyprexa cases. It is important to make your claim in a timely manner.
Lawyers agreed to an early settlement with Eli Lilly and Co. on 8,000
claims of damages over the company's top-selling drug Zyprexa.
A $690 million settlement was announced June 9, 2005 after only five plaintiffs had given depositions in the mass litigation and before any substantive depositions had been taken from Lilly executives or scientists.
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Diabetic Hyperosmolar Syndrome from Zyprexa
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In the presence of a hyperglycemic, hyperosmolar state, if the renal water loss is not compensated by oral water intake, then hypovolemia follows dehydration. Hypovolemia, in turn, leads to hypotension, and hypotension results in impaired tissue perfusion. Coma is the end stage of this hyperglycemic process, when severe electrolyte disturbances occur in association with hypotension. Any process that accelerates water loss, such as diarrhea or severe burns, accelerates the development of hyperosmolarity and hypotension. In this severely dehydrated and hyperosmolar state, hypotension causes a massive stimulation of the renin-angiotensin-aldosterone system and, eventually, renal shutdown. Oliguria precludes further excretion of glucose from the kidneys, which conserves circulating volume but exacerbates hyperglycemia.
If blood sugar increases to dangerously high levels, the blood thickens and begins to pass the high levels of sugar into the kidneys. This condition is known as diabetic hyperosmolar syndrome (DHS). To compensate for the increased levels of sugar they are forced to excrete, the kidneys divert unusually large quantities of fluids from the body. This can result in severe dehydration and can be amplified by the effects of anti-diabetic medications that increase urine output. DHS can develop over a period of days or weeks.
Symptoms of DHS include increased or excessive thirst, dry mouth, frequent urination, muscle cramps, insomnia, restlessness, confusion and fever. Any one experiencing these symptoms should seek medical treatment immediately.
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Law Offices of Michael Monheit 1368 Barrowdale Road Rydal, PA 19046
Call Us Toll Free: 866-761-1385 P: 215-840-6573 E: Michael@Monheit.com
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