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Wyeth
Pharmaceuticals, a division of Wyeth (NYSE:WYE), is responsible for the
predominance of the side-effects of Prempro and the injuries being pursued in Prempro litigation. Menopausal
and postmenopausal women have been repeatedly and erroneously over prescribed
by their physicians indicating that Prempro should be taken indefinitely.
Inappropriate Prempro labeling that failed to fully describe the side-effects of Prempro
and long-term dosage has created many serious
and life threatening health risks for women. It is the responsibility
of the drug manufacturer to protect women from harmful Prempro injury and to warn of the side
effects of Prempro.
Prempro litigation began after an article published in the Journal of
the American Medical Association (AMA) revealed that the side-effects of Wyeth's Prempro
included increased risk of probable dementia in postmenopausal women 65 years
or older.
The Women's Health Initiative (WHI) Memory Study enrolled 4,532 postmenopausal
women free of probable dementia aged 65 years or older. Participants received
either one daily Prempro tablet or a matching placebo in a randomized,
double-blind, placebo-controlled clinical trial.
The results of the memory study showed the following side-effects of Prempro: 66 percent of the 61 women
diagnosed with probable dementia were receiving Prempro. This staggering
statistic gave an increased risk of an additional 23 cases of dementia
per 10,000 women per year. Additionally, the results coupled with previously
reported Women's Health Initiative data suggest that the risks of
Prempro injury outweigh the benefits. As such, this study has been central
to describing the side-effects of Premprto that are at the heart of the Prempro litigation.
Alzheimer's disease (AD), the most common form of dementia, is thought
to affect 10 percent of adults over 65 years old, with women at greater
risk. One theory is that lower levels of estrogen may increase the risks
of dementia in postmenopausal women. Numerous studies suggest that women
taking HRT have less risk of dementia.
However, the vast majority of studies have failed to separate the use
of estrogen alone and estrogen plus progestin and these latest results
appear to contradict earlier findings. This raises the question as to
which component of the drug is responsible for the side-effects of Prempro, such as
increasing the risk of
dementia. This debate is being played out in the courtrooms handling
litigation involving the side-effects of Prempro.
Prempro has also previously come under fire following the termination
of the WHI long-term study because of increased ovarian cancer risks,
heart attacks, and strokes. Further investigation into the association
of estrogen therapies and dementia is now warranted.
Are you, a family member, or dear friend suffering from an injury due to the dangerous side-effects of Prempro?
Then you may want to discuss the options for Prempro litigation.
To find out if you may have a case for injury from the side-effects of Prempro, please complete the FREE
no-obligation case consultation form.
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